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KMID : 1007320110170030166
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Journal of the Korean Society of Menopause
2011 Volume.17 No. 3 p.166 ~ p.173
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Serum Ferritin and Metabolic Syndrome in Perimenopausal and Postmenopausal Women
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Cho Soo-Hyun
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Abstract
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Objectives: The purpose of this study was to examine the relationship between serum ferritin and metabolic syndrome in peri- and postmenopausal women.
Methods: The study subjects consisted of 2,091 peri- and postmenopausal women who visited the hospital for a health check-up in 2007. They were divided into the metabolic syndrome group (MetS) and the non-metabolic syndrome group (Non-MetS).
Results: Mean serum ferritin values were 65.16 ± 33.69 ng/mL in MetS and 57.82 ± 32.51 ng/mL in Non-MetS (P = 0.000). In MetS, serum ferritin had a positive correlation with hemoglobin (Hb), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride, aspartate transaminase (SGOT), alanine transaminase (SGPT), uric acid, and high-sensitivity C-reactive protein (hs-CRP) but a negative correlation with high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol (P ＜ 0.05). From multiple linear models, hs-CRP, HDL-cholesterol, SGOT, HOMA-IR, and hemoglobin level were found to be the best predictors of serum ferritin in MetS (R2 = 0.106; P ＜ 0.05).
Conclusion: The serum ferritin level in MetS was higher than in Non-MetS in postmenopausal women. In MetS, with increasing hs-CRP, SGOT, HOMA-IR, and hemoglobin levels and decreasing HDL-cholesterol levels, the serum ferritin level seems to increase. (J Korean Soc Menopause 2011;17:166-173)
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KEYWORD
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Atherosclerosis, Cardiovascular diseases, Ferritins, Metabolic Syndrome, Postmenopause, Women
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